Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs

Nitric oxide (NO) prodrugs such as O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) are a growing class of promising NO-based therapeutics. Nitric oxide release from the anti-cancer lead compound, JS-K, is proposed to occur through a nucleophilic aromatic...

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Main Authors: Chakrapani, Harinath, Kalathur, Ravi C., Maciag, Anna E., Citro, Michael L., Ji, Xinhua, Keefer, Larry K., Saavedra, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631660/
https://ncbi.nlm.nih.gov/pubmed/18930407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.09.063
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