The Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia

BACKGROUND AND PURPOSE: p53-upregulated modulator of apoptosis (PUMA), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis. PUMA localizes to mitochondria and interacts with anti-apoptotic Bcl-2 and Bcl-X(L) or pro-apoptotic Bax in respons...

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Bibliografiska uppgifter
Huvudupphovsmän: Niizuma, Kuniyasu, Endo, Hidenori, Nito, Chikako, Myer, D. Jeannie, Chan, Pak H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631621/
https://ncbi.nlm.nih.gov/pubmed/19095966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.108.524447
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