Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A(2) signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion

Cytosolic phospholipase A(2) (cPLA(2)) is a key enzyme that mediates arachidonic acid metabolism, which causes cerebral ischemia-induced oxidative injury, blood-brain barrier (BBB) dysfunction, and edema. Recent reports have shown that p38 mitogen-activated protein kinase (MAPK) is related to phosph...

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Detalhes bibliográficos
Main Authors: Nito, Chikako, Kamada, Hiroshi, Endo, Hidenori, Niizuma, Kuniyasu, Myer, D Jeannie, Chan, Pak H
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562626/
https://ncbi.nlm.nih.gov/pubmed/18545259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.60
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