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Role of budding yeast Rad18 in repair of HO-induced double-strand breaks
The Rad6-Rad18 complex mono-ubiquitinates proliferating cell nuclear antigen (PCNA) at the lysine 164 residue after DNA damage and promotes DNA polymerase η (Polη)- and Polζ/Rev1-dependent DNA synthesis. Double-strand breaks (DSBs) of DNA can be repaired by homologous recombination (HR) or non-homol...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631570/ https://ncbi.nlm.nih.gov/pubmed/18824138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.08.013 |
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