The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

Interleukin-8 (IL-8) promotes neutrophil-mediated host defense through its chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upregulated in vivo in the M1T1 GAS strains associated with...

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Hauptverfasser: Zinkernagel, Annelies S., Timmer, Anjuli M., Pence, Morgan A., Locke, Jeffrey B., Buchanan, John T., Turner, Claire E., Mishalian, Inbal, Sriskandan, Shiranee, Hanski, Emanuel, Nizet, Victor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631432/
https://ncbi.nlm.nih.gov/pubmed/18692776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.07.002
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