Loss of viral fitness and cross-recognition by CD8(+) T cells limit HCV escape from a protective HLA-B27–restricted human immune response

There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8(+) T cells. If HIV mutates the HLA...

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Main Authors: Dazert, Eva, Neumann-Haefelin, Christoph, Bressanelli, Stéphane, Fitzmaurice, Karen, Kort, Julia, Timm, Jörg, McKiernan, Susan, Kelleher, Dermot, Gruener, Norbert, Tavis, John E., Rosen, Hugo R., Shaw, Jaqueline, Bowness, Paul, Blum, Hubert E., Klenerman, Paul, Bartenschlager, Ralf, Thimme, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631298/
https://ncbi.nlm.nih.gov/pubmed/19139562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36587
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