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Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor—Cobalamin Complex Crystals

Approximately 15% (w/w) of human intrinsic factor (IF) is comprised of carbohydrate side chains, making crystallization problematic. In addition, IF is sensitive to proteolysis. To understand the role of these factors in crystallization, we carried out dynamic light scattering studies and assessed t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sukumar, N., Mathews, F. S., Gordon, M. M., Ealick, S. E., Alpers, D. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631276/
https://ncbi.nlm.nih.gov/pubmed/19884970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cg800509f
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