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Correction of Cobalamin Malabsorption in Pancreatic Insufficiency with a Cobalamin Analogue that Binds with High Affinity to R Protein but not to Intrinsic Factor

In vitro studies indicate that [(57)Co]cobalamin (Cbl) is preferentially bound to salivary R protein as opposed to intrinsic factor (IF) and that [(57)Co]Cbl bound to R protein is not transferred to IF at either pH 2 or pH 8. Incubation of R protein-[(57)Co]Cbl with pancreatic proteases causes a par...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Allen, Robert H., Seetharam, Bellur, Allen, Nancy C., Podell, Elaine R., Alpers, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1978
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372689/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/659618/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109083
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