Correction of Cobalamin Malabsorption in Pancreatic Insufficiency with a Cobalamin Analogue that Binds with High Affinity to R Protein but not to Intrinsic Factor: IN VIVO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY

In vitro studies indicate that [(57)Co]cobalamin (Cbl) is preferentially bound to salivary R protein as opposed to intrinsic factor (IF) and that [(57)Co]Cbl bound to R protein is not transferred to IF at either pH 2 or pH 8. Incubation of R protein-[(57)Co]Cbl with pancreatic proteases causes a par...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Allen, Robert H., Seetharam, Bellur, Allen, Nancy C., Podell, Elaine R., Alpers, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1978
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC372689/
https://ncbi.nlm.nih.gov/pubmed/659618
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky