Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats.

In man, use of the general anesthetic nitrous oxide, N2O, is associated with hematologic and neurologic abnormalities that mimic those seen in cobalamin (Cbl, vitamin B12) deficiency. We have measured a number of aspects of Cbl metabolism in rts exposed to various concentrations of N2O for various p...

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Udgivet i:J Clin Invest
Main Authors: Kondo, H, Osborne, M L, Kolhouse, J F, Binder, M J, Podell, E R, Utley, C S, Abrams, R S, Allen, R H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370693/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6112240/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110155
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