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Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades
The TSH receptor (TSHR) is constitutively active and is further enhanced by TSH ligand binding or by stimulating TSHR antibodies (TSHR-Abs) as seen in Graves’ disease. TSH is known to activate the thyroid epithelial cell via both Gαs-cAMP/protein kinase A/ERK and Gαq-Akt/protein kinase C coupled sig...
Shranjeno v:
| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Endocrine Society
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630889/ https://ncbi.nlm.nih.gov/pubmed/18719020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0878 |
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