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Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades

The TSH receptor (TSHR) is constitutively active and is further enhanced by TSH ligand binding or by stimulating TSHR antibodies (TSHR-Abs) as seen in Graves’ disease. TSH is known to activate the thyroid epithelial cell via both Gαs-cAMP/protein kinase A/ERK and Gαq-Akt/protein kinase C coupled sig...

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Hlavní autoři: Morshed, Syed A., Latif, Rauf, Davies, Terry F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630889/
https://ncbi.nlm.nih.gov/pubmed/18719020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0878
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