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Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells

Telomerase activity is downregulated in somatic cells but is upregulated during the activation of cells of the immune system. The mechanism of this reactivation is not well understood. In this study, we demonstrated that interferon regulatory factor 4 (IRF-4) and, to a lesser extent, IRF-8 induce te...

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Autori principali: Hrdličková, Radmila, Nehyba, Jiří, Bose, Henry R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630682/
https://ncbi.nlm.nih.gov/pubmed/19047367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00961-08
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