Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

FK506 binding protein 12 (FKBP12) binds the immunosuppressant drugs FK506 and rapamycin and regulates several signaling pathways, including mammalian target of rapamycin (mTOR) signaling. We determined whether the brain-specific disruption of the FKBP12 gene altered mTOR signaling, synaptic plastici...

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Autori principali: Hoeffer, Charles A., Tang, Wei, Wong, Helen, Santillan, Arturo, Patterson, Richard J., Martinez, Luis A., Tejada-Simon, Maria V., Paylor, Richard, Hamilton, Susan L., Klann, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630531/
https://ncbi.nlm.nih.gov/pubmed/19081378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.09.037
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