An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR

Mammalian target of rapamycin (mTOR), a large multidomain protein kinase, regulates cell growth and metabolism in response to environmental signals. The FKBP rapamycin-binding (FRB) domain of mTOR is a validated therapeutic target for the development of immunosuppressant and anticancer drugs but is...

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Detalhes bibliográficos
Main Authors: Sekiguchi, Mitsuhiro, Kobashigawa, Yoshihiro, Kawasaki, Masashi, Yokochi, Masashi, Kiso, Tetsuo, Suzumura, Ken-ichi, Mori, Keitaro, Teramura, Toshio, Inagaki, Fuyuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196870/
https://ncbi.nlm.nih.gov/pubmed/21900305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr045
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