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Crystal Structure of a p53 Core Tetramer Bound to DNA

The tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is frequently mutated in human cancers. Here, we report the use of a crosslinking strategy to trap a tetrameric p53 DNA binding domain (p53DBD) bound to DNA and the X-ray crystal structure of the protein/DN...

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Main Authors: Malecka, Kimberly A., Ho, William C., Marmorstein, Ronen
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629805/
https://ncbi.nlm.nih.gov/pubmed/18978813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.400
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