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Full-length p53 Tetramer Bound to DNA and Its Quaternary Dynamics
p53 is a major tumor suppressor that is mutated and inactivated in about 50% of all human cancers. Thus, reactivation of mutant p53 using small-molecules has been a long sought-after anti-cancer therapeutic strategy. Full structural characterization of the full-length oligomeric p53 is challenging b...
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| Publicado no: | Oncogene |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344712/ https://ncbi.nlm.nih.gov/pubmed/27641333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.321 |
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