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CTCF-dependent enhancer-blocking by alternative chromatin loop formation
The mechanism underlying enhancer-blocking by insulators is unclear. We explored the activity of human β-globin HS5, the orthologue of the CTCF-dependent chicken HS4 insulator. An extra copy of HS5 placed between the β-globin locus control region (LCR) and downstream genes on a transgene fulfills th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629272/ https://ncbi.nlm.nih.gov/pubmed/19074263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808506106 |
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