CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we demonstrate that a 79-aa region within the CTCF N terminus is essential for cohesin pos...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pugacheva, Elena M., Kubo, Naoki, Loukinov, Dmitri, Tajmul, Md, Kang, Sungyun, Kovalchuk, Alexander L., Strunnikov, Alexander V., Zentner, Gabriel E., Ren, Bing, Lobanenkov, Victor V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995019/
https://ncbi.nlm.nih.gov/pubmed/31937660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911708117
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