The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer states. Unexpectedly, BORIS-null mice have only minimal germ cell defects. To understand the CTCF-BORIS relationship, mouse models with varied CT...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Rivero-Hinojosa, Samuel, Pugacheva, Elena M., Kang, Sungyun, Méndez-Catalá, Claudia Fabiola, Kovalchuk, Alexander L., Strunnikov, Alexander V., Loukinov, Dmitri, Lee, Jeannie T., Lobanenkov, Victor V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219828/
https://ncbi.nlm.nih.gov/pubmed/34158481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24140-6
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