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Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
The NS3 helicase from hepatitis C virus is a prototypical DEx(H/D) RNA helicase. NS3 has been shown to unwind RNA in a discontinuous manner, pausing after long apparent steps of unwinding. We systematically examined the effects of duplex stability and ionic conditions on the periodicity of the NS3 u...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629105/ https://ncbi.nlm.nih.gov/pubmed/19010782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805460200 |
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