Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase

Non-structural protein 3 (NS3) is a multifunctional enzyme possessing serine protease, NTPase, and RNA unwinding activities that are required for hepatitis C viral (HCV) replication. HCV non-structural protein 4A (NS4A) binds to the N-terminal NS3 protease domain to stimulate NS3 serine protease act...

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Bibliographic Details
Main Authors: Beran, Rudolf K. F., Pyle, Anna Marie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573085/
https://ncbi.nlm.nih.gov/pubmed/18723512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804065200
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