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Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks

BACKGROUND: High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications, changes in chromatin structure and patterns of DNA methylation across entire genomes. In these experiments, chromatin i...

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Hlavní autoři: Nix, David A, Courdy, Samir J, Boucher, Kenneth M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628906/
https://ncbi.nlm.nih.gov/pubmed/19061503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-523
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