Auxilin Depletion Causes Self-Assembly of Clathrin into Membraneless Cages In Vivo

Auxilin is a cofactor for Hsc70-mediated uncoating of clathrin-coated vesicles (CCVs). However, small interfering RNA (siRNA) knockdown of the ubiquitous auxilin 2 in HeLa cells only moderately impairs clathrin-dependent trafficking. In this study, we show that HeLa cells also express auxilin 1, pre...

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Detalhes bibliográficos
Main Authors: Hirst, Jennifer, Sahlender, Daniela A, Li, Sam, Lubben, Nienke B, Borner, Georg H H, Robinson, Margaret S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628426/
https://ncbi.nlm.nih.gov/pubmed/18489706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2008.00764.x
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