Hsc70-induced Changes in Clathrin-Auxilin Cage Structure Suggest a Role for Clathrin Light Chains in Cage Disassembly

The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells. We have used cryo-electron microscopy to determine the 3D structure of a complex of clathrin, auxilin(401-910) and Hsc70 at pH 6 in t...

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Detalhes bibliográficos
Main Authors: Young, Anna, Stoilova-McPhie, Svetla, Rothnie, Alice, Vallis, Yvonne, Harvey-Smith, Phillip, Ranson, Neil, Kent, Helen, Brodsky, Frances M, Pearse, Barbara M F, Roseman, Alan, Smith, Corinne J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons A/S 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776051/
https://ncbi.nlm.nih.gov/pubmed/23710728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12085
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