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Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

Hepcidin plays a major role in the regulation of iron homeostasis. Several bone morphogenetic proteins (BMPs) are strong inducers of hepcidin (Hamp1, HAMP) expression. Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby prov...

詳細記述

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書誌詳細
主要な著者: Truksa, Jaroslav, Lee, Pauline, Beutler, Ernest
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628375/
https://ncbi.nlm.nih.gov/pubmed/18997172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-160184
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