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Ceramide activates JNK to inhibit a cAMP-gated K(+) conductance and Cl(–) secretion in intestinal epithelia

Sphingomyelinases (SMases) hydrolyze membrane sphingomyelin to ceramide and are expressed by diverse host and microbial cell types populating mucosal surfaces. Exogenous bacterial SMase acts on the basolateral membrane of polarized human intestinal epithelial cells to repress the cAMP-induced Cl(−)...

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Autors principals: Saslowsky, David E., Tanaka, Noriyuki, Reddy, Krishna P., Lencer, Wayne I.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626619/
https://ncbi.nlm.nih.gov/pubmed/18820034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-116467
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