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Ceramide activates JNK to inhibit a cAMP-gated K(+) conductance and Cl(–) secretion in intestinal epithelia
Sphingomyelinases (SMases) hydrolyze membrane sphingomyelin to ceramide and are expressed by diverse host and microbial cell types populating mucosal surfaces. Exogenous bacterial SMase acts on the basolateral membrane of polarized human intestinal epithelial cells to repress the cAMP-induced Cl(−)...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Federation of American Societies for Experimental Biology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626619/ https://ncbi.nlm.nih.gov/pubmed/18820034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-116467 |
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