Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

This study demonstrates that in malignant melanoma, elevated levels of nuclear ß-catenin in both primary tumors and metastases correlate with reduced expression of a marker of proliferation and with improved survival, in contrast to colorectal cancer. The reduction in proliferation observed in vivo...

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Detalhes bibliográficos
Main Authors: Chien, Andy J., Moore, Erin C., Lonsdorf, Anke S., Kulikauskas, Rima M., Rothberg, Bonnie Gould, Berger, Aaron J., Major, Michael B., Hwang, Sam T., Rimm, David L., Moon, Randall T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626610/
https://ncbi.nlm.nih.gov/pubmed/19144919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811902106
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