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Nonspecific Double-Stranded DNA Binding Activity of Simian Virus 40 Large T Antigen Is Involved in Melting and Unwinding of the Origin

Helicase activity is required for T antigen to unwind the simian virus 40 origin. We previously mapped this activity to residues 131 and 616. In this study, we generated a series of mutants with single-point substitutions in the helicase domain to discover other potential activities required for hel...

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Bibliografiske detaljer
Main Authors: Jiao, Junfang, Simmons, Daniel T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC262600/
https://ncbi.nlm.nih.gov/pubmed/14610194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.23.12720-12728.2003
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