The Cap Region of Topoisomerase I Binds to Sites near Both Ends of Simian Virus 40 T Antigen

Two independent binding sites on simian virus 40 (SV40) T antigen for topoisomerase I (topo I) were identified. One was mapped to the N-terminal domain (residues 83 to 160) by a combination of enzyme-linked immunosorbent assays (ELISAs) and glutathione S-transferase (GST) pull-down assays performed...

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Bibliographic Details
Main Authors: Roy, Rupa, Trowbridge, Pamela, Yang, Zheng, Champoux, James J., Simmons, Daniel T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC224608/
https://ncbi.nlm.nih.gov/pubmed/12941889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.9809-9816.2003
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