Combinatorial optimization of a CD4-mimetic miniprotein and co-crystal structures with HIV-1 gp120 envelope glycoprotein

Miniproteins provide a bridge between proteins and small molecules. Here we adapt methods from combinatorial chemistry to optimize CD4M33, a synthetic miniprotein into which we had previously transplanted the HIV-1 gp120 binding surface of the CD4 receptor. Iterative deconvolution of generated libra...

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Autors principals: Stricher, François, Huang, Chih-chin, Descours, Anne, Duquesnoy, Sophie, Combes, Olivier, Decker, Julie M., Kwon, Young Do, Lusso, Paolo, Shaw, George M., Vita, Claudio, Kwong, Peter D., Martin, Loïc
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625307/
https://ncbi.nlm.nih.gov/pubmed/18619974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.069
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