The Mechanism of Nucleotide Incorporation by Human DNA Polymerase η Differs from That of the Yeast Enzyme

DNA polymerase η (Polη) catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers, and inactivation of Polη in humans causes the cancer-prone syndrome, the variant form of xeroderma pigmentosum. Pre-steady-state kinetic studies of yeast Polη have indicated that the...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Washington, M. Todd, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2003
Schlagworte:	DNA Dynamics and Chromosome Structure
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262418/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585988/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8316-8322.2003
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