Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

Substrates of the ubiquitin-dependent N-end rule pathway include proteins with destabilizing N-terminal residues. UBR1(−/−) mice, which lacked the pathway's ubiquitin ligase E3α, were viable and retained the N-end rule pathway. The present work describes the identification and analysis of mouse...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Kwon, Yong Tae, Xia, Zanxian, An, Jee Young, Tasaki, Takafumi, Davydov, Ilia V., Seo, Jai Wha, Sheng, Jun, Xie, Youming, Varshavsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262401/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585983/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8255-8271.2003
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