Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

Substrates of the ubiquitin-dependent N-end rule pathway include proteins with destabilizing N-terminal residues. UBR1(−/−) mice, which lacked the pathway's ubiquitin ligase E3α, were viable and retained the N-end rule pathway. The present work describes the identification and analysis of mouse UBR2...

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Publicado en:	Mol Cell Biol
Autores principales:	Kwon, Yong Tae, Xia, Zanxian, An, Jee Young, Tasaki, Takafumi, Davydov, Ilia V., Seo, Jai Wha, Sheng, Jun, Xie, Youming, Varshavsky, Alexander
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2003
Materias:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585983/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8255-8271.2003
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