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Human Heterochromatin Protein 1 Isoforms HP1(Hsα) and HP1(Hsβ) Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

Telomeres are associated with the nuclear matrix and are thought to be heterochromatic. We show here that in human cells the overexpression of green fluorescent protein-tagged heterochromatin protein 1 (GFP-HP1) or nontagged HP1 isoforms HP1(Hsα) or HP1(Hsβ), but not HP1(Hsγ), results in decreased a...

Deskribapen osoa

Gorde:
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: Sharma, Girdhar G., Hwang, Kyu-kye, Pandita, Raj K., Gupta, Arun, Dhar, Sonu, Parenteau, Julie, Agarwal, Manjula, Worman, Howard J., Wellinger, Raymund J., Pandita, Tej K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2003
Gaiak:
Cell Growth and Development
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262350/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585993/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8363-8376.2003
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