Human Heterochromatin Protein 1 Isoforms HP1(Hsα) and HP1(Hsβ) Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

Telomeres are associated with the nuclear matrix and are thought to be heterochromatic. We show here that in human cells the overexpression of green fluorescent protein-tagged heterochromatin protein 1 (GFP-HP1) or nontagged HP1 isoforms HP1(Hsα) or HP1(Hsβ), but not HP1(Hsγ), results in decreased a...

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Main Authors: Sharma, Girdhar G., Hwang, Kyu-kye, Pandita, Raj K., Gupta, Arun, Dhar, Sonu, Parenteau, Julie, Agarwal, Manjula, Worman, Howard J., Wellinger, Raymund J., Pandita, Tej K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC262350/
https://ncbi.nlm.nih.gov/pubmed/14585993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8363-8376.2003
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