Human Heterochromatin Protein 1 Isoforms HP1(Hsα) and HP1(Hsβ) Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

Telomeres are associated with the nuclear matrix and are thought to be heterochromatic. We show here that in human cells the overexpression of green fluorescent protein-tagged heterochromatin protein 1 (GFP-HP1) or nontagged HP1 isoforms HP1(Hsα) or HP1(Hsβ), but not HP1(Hsγ), results in decreased a...

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Detalhes bibliográficos
Main Authors: Sharma, Girdhar G., Hwang, Kyu-kye, Pandita, Raj K., Gupta, Arun, Dhar, Sonu, Parenteau, Julie, Agarwal, Manjula, Worman, Howard J., Wellinger, Raymund J., Pandita, Tej K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262350/
https://ncbi.nlm.nih.gov/pubmed/14585993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8363-8376.2003
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