Sox3 Is Required for Gonadal Function, but Not Sex Determination, in Males and Females

Sox3 is expressed in developing gonads and in the brain. Evolutionary evidence suggests that the X-chromosomal Sox3 gene may be the ancestral precursor of Sry, a sex-determining gene, and Sox3 has been proposed to play a role in sex determination. However, patients with mutations in SOX3 exhibit nor...

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Detalhes bibliográficos
Main Authors: Weiss, Jeffrey, Meeks, Joshua J., Hurley, Lisa, Raverot, Gerald, Frassetto, Andrea, Jameson, J. Larry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262333/
https://ncbi.nlm.nih.gov/pubmed/14585968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8084-8091.2003
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