Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

During mammalian sex determination, expression of the Y-linked gene Sry shifts the bipotential gonad toward a testicular fate by upregulating a feed-forward loop between FGF9 and SOX9 to establish SOX9 expression in somatic cells. We previously proposed that these signals are mutually antagonistic w...

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Bibliographic Details
Main Authors: Maatouk, Danielle M., DiNapoli, Leo, Alvers, Ashley, Parker, Keith L., Taketo, Makoto M., Capel, Blanche
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536503/
https://ncbi.nlm.nih.gov/pubmed/18617533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn193
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