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Lytic Granule Loading of CD8(+) T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

Virus-specific CD8(+) T cells probably mediate control over HIV replication in rare individuals, termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive investigation, the mechanisms responsible for this control remain incompletely understood. We observed that HIV-specific CD...

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Hlavní autoři: Migueles, Stephen A., Osborne, Christine M., Royce, Cassandra, Compton, Alex A., Joshi, Rohan P., Weeks, Kristin A., Rood, Julia E., Berkley, Amy M., Sacha, Jonah B., Cogliano-Shutta, Nancy A., Lloyd, Margaret, Roby, Gregg, Kwan, Richard, McLaughlin, Mary, Stallings, Sara, Rehm, Catherine, O’Shea, Marie A., Mican, JoAnn, Packard, Beverly Z., Komoriya, Akira, Palmer, Sarah, Wiegand, Ann P., Maldarelli, Frank, Coffin, John M., Mellors, John W., Hallahan, Claire W., Follman, Dean A., Connors, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2622434/
https://ncbi.nlm.nih.gov/pubmed/19062316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.10.010
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