Lytic Granule Loading of CD8(+) T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

Virus-specific CD8(+) T cells probably mediate control over HIV replication in rare individuals, termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive investigation, the mechanisms responsible for this control remain incompletely understood. We observed that HIV-specific CD...

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Main Authors: Migueles, Stephen A., Osborne, Christine M., Royce, Cassandra, Compton, Alex A., Joshi, Rohan P., Weeks, Kristin A., Rood, Julia E., Berkley, Amy M., Sacha, Jonah B., Cogliano-Shutta, Nancy A., Lloyd, Margaret, Roby, Gregg, Kwan, Richard, McLaughlin, Mary, Stallings, Sara, Rehm, Catherine, O’Shea, Marie A., Mican, JoAnn, Packard, Beverly Z., Komoriya, Akira, Palmer, Sarah, Wiegand, Ann P., Maldarelli, Frank, Coffin, John M., Mellors, John W., Hallahan, Claire W., Follman, Dean A., Connors, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2622434/
https://ncbi.nlm.nih.gov/pubmed/19062316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.10.010
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