Interferon-β Sensitizes Neuroblastoma to the Anti-Tumor Activity of Temozolomide by Modulating O(6)-Methylguanine-DNA Methyltransferase Expression

PURPOSE: Although temozolomide (TMZ) has shown clinical activity against neuroblastoma, this activity is likely limited by the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT). We hypothesized that interferon-beta (IFN-β) could sensitize neuroblastoma cells to the cytotoxic effects...

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Hauptverfasser: Rosati, Shannon F., Williams, Regan F., Nunnally, Lindsey C., McGee, Mackenzie C., Sims, Thomas L., Tracey, Lorraine, Zhou, Junfang, Fan, Meiyun, Ng, Catherine Y., Nathwani, Amit C., Stewart, Clinton F., Pfeffer, Lawrence M., Davidoff, Andrew M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621272/
https://ncbi.nlm.nih.gov/pubmed/19056675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0806
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