Interferon-β Sensitizes Neuroblastoma to the Anti-Tumor Activity of Temozolomide by Modulating O(6)-Methylguanine-DNA Methyltransferase Expression

PURPOSE: Although temozolomide (TMZ) has shown clinical activity against neuroblastoma, this activity is likely limited by the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT). We hypothesized that interferon-beta (IFN-β) could sensitize neuroblastoma cells to the cytotoxic effects...

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Detalhes bibliográficos
Main Authors: Rosati, Shannon F., Williams, Regan F., Nunnally, Lindsey C., McGee, Mackenzie C., Sims, Thomas L., Tracey, Lorraine, Zhou, Junfang, Fan, Meiyun, Ng, Catherine Y., Nathwani, Amit C., Stewart, Clinton F., Pfeffer, Lawrence M., Davidoff, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621272/
https://ncbi.nlm.nih.gov/pubmed/19056675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0806
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