Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

Alzheimer's disease (AD) is characterized by three primary pathologies in the brain: amyloid plaques, neurofibrillary tangles, and neuron loss. Mouse models have been useful for studying components of AD but are limited in their ability to fully recapitulate all pathologies. We crossed the APPS...

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Bibliographic Details
Main Authors: Wilcock, Donna M., Lewis, Matthew R., Van Nostrand, William E., Davis, Judianne, Previti, Mary Lou, Gharkholonarehe, Nastaran, Vitek, Michael P., Colton, Carol A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621082/
https://ncbi.nlm.nih.gov/pubmed/18272675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5066-07.2008
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