Multiple Anaphase-promoting Complex/Cyclosome Degrons Mediate the Degradation of Human Sgo1

Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion in early mitosis and, thus, prevents premature sister-chromatid separation. The protein level of Sgo1 is regulated during the cell cycle; it peaks in mitosis and is down-regulated in G(1)/S. Here we show that Sgo1 is degraded during t...

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Bibliografiske detaljer
Main Authors: Karamysheva, Zemfira, Diaz-Martinez, Laura A., Crow, Sara E., Li, Bing, Yu, Hongtao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615523/
https://ncbi.nlm.nih.gov/pubmed/19015261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807083200
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