The HECT Type Ubiquitin Ligase NEDL2 Is Degraded by Anaphase-promoting Complex/Cyclosome (APC/C)-Cdh1, and Its Tight Regulation Maintains the Metaphase to Anaphase Transition

NEDD4-like ubiquitin ligase 2 (NEDL2) is a HECT type ubiquitin ligase. NEDL2 enhances p73 transcriptional activity and degrades ATR kinase in lamin misexpressed cells. Compared with the important functions of other HECT type ubiquitin ligase, there is less study concerning the function and regulatio...

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Detalhes bibliográficos
Main Authors: Lu, Li, Hu, Shaohua, Wei, Rongfei, Qiu, Xiao, Lu, Kefeng, Fu, Yesheng, Li, Hongchang, Xing, Guichun, Li, Dong, Peng, Ruiyun, He, Fuchu, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861616/
https://ncbi.nlm.nih.gov/pubmed/24163370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472076
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