NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner

The GDNF (Glial cell line-derived neurotrophic factor)/Ret/Akt signaling pathway is essential to the development of ENS (enteric nervous system) as well as kidney. We previously showed that the HECT-type E3 ligase NEDL2 (Nedd4-like ligase 2) is required for the ENS development by activating GDNF/Ret...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Qiu, Xiao, Wei, Rongfei, Li, Yang, Zhu, Qiong, Xiong, Cong, Chen, Yuhan, Zhang, Yuan, Lu, Kefeng, He, Fuchu, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058769/
https://ncbi.nlm.nih.gov/pubmed/27119228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8951
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