Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions

Side chain oxysterols exert cholesterol homeostatic effects by suppression of sterol regulatory element-binding protein maturation and promoting degradation of hydroxymethylglutaryl-CoA reductase. To examine whether oxysterol-membrane interactions contribute to the regulation of cellular cholesterol...

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Autori principali: Gale, Sarah E., Westover, Emily J., Dudley, Nicole, Krishnan, Kathiresan, Merlin, Sean, Scherrer, David E., Han, Xianlin, Zhai, Xiuhong, Brockman, Howard L., Brown, Rhoderick E., Covey, Douglas F., Schaffer, Jean E., Schlesinger, Paul, Ory, Daniel S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615513/
https://ncbi.nlm.nih.gov/pubmed/18996837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807210200
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