S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

Proteolytic processing of amyloid precursor protein (APP) by β- and γ-secretases generates β-amyloid (Aβ) peptides, which accumulate in the brains of individuals affected by Alzheimer disease. Detergent-resistant membrane microdomains (DRM) rich in cholesterol and sphingolipid, termed lipid rafts, h...

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書誌詳細
主要な著者: Cheng, Haipeng, Vetrivel, Kulandaivelu S., Drisdel, Renaldo C., Meckler, Xavier, Gong, Ping, Leem, Jae Yoon, Li, Tong, Carter, Meghan, Chen, Ying, Nguyen, Phuong, Iwatsubo, Takeshi, Tomita, Taisuke, Wong, Philip C., Green, William N., Kounnas, Maria Z., Thinakaran, Gopal
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
Protein Synthesis, Post-Translational Modification, and Degradation
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615504/
https://ncbi.nlm.nih.gov/pubmed/19028695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806380200
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