The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway

PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms associated with this pathway have not been elucidated. The Akt-mTOR-P70S...

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Bibliografiska uppgifter
Huvudupphovsmän: Park, Sungha, Lim, Soyeon, Chang, Woochul, Song, Heesang, Lee, Sunju, Song, Byeong-Wook, Kim, Hye-Jung, Cha, Min-Ji, Choi, Eunju, Jang, Yangsoo, Chung, Namsik, Cho, Seung Yun, Hwang, Ki-Chul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Yonsei University College of Medicine 2008
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615285/
https://ncbi.nlm.nih.gov/pubmed/18729301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2008.49.4.592
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