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Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

Constitutively active, ‘oncogenic’ H-RAS can drive proliferation and transformation in human cancer, or be a potent inducer of cellular senescence. Moreover, aberrant activation of the Ras pathway owing to germline mutations can cause severe developmental disorders. In this study we have generated t...

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Detalhes bibliográficos
Main Authors: Santoriello, Cristina, Deflorian, Gianluca, Pezzimenti, Federica, Kawakami, Koichi, Lanfrancone, Luisa, d’Adda di Fagagna, Fabrizio, Mione, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615164/
https://ncbi.nlm.nih.gov/pubmed/19132118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.001016
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